Assertion:
Creating "cut-out" shapes: If you wish to create a geometric shape, and then have a region inside defined within as NOHREF, the NOHREF region must occur FIRST - If it is placed after, the NOHREF region will still be active. This appears to hold true for the browsers that support CSIM. Internet Explorer 4.0, however, had a bug - "cut-out" shapes did not work at all, whether the NOHREF occurred before OR after the active region.

Image map (#imgmap1), with no cut-out shape defined:
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Image map (#imgmap2), with NOHREF cut-out shape (inner white circle) defined before the yellow circle shape:
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Image map (#imgmap3), with NOHREF cut-out shape (inner white circle) defined after the yellow circle shape:
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Shape destinations on image, no default destination:
ShapeURL
http://www.blooberry.com/